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Job Description
Objective / Purpose:
Global Biologics (GB) mission is the discovery of transformative innovative biologics therapeutics to support Takeda’s pipeline and advance novel therapeutics into clinical development in Takeda’s three therapeutic areas of interest: Oncology, Gastroenterology and Neuroscience.
Biologics In Vitro Pharmacology (BIVP) role is to identify the therapeutics candidates that have the desired biological activity and select the best candidates for further preclinical and clinical development.
This role will provide essential scientific guidance and make strategic decisions to ensure the delivery of the critical functions of BIVP.
ACCOUNTABILITIES:
- Lead the functional screening strategy and candidate selection for biologics projects in the gastrointestinal, inflammatory diseases, and fibrosis therapeutic areas.
- Independently designs mechanism of action-relevant functional assays. Develop and validate new functional assays and execute research experimental plan with high scientific rigor.
- Oversees novel scientific projects and manages the workflow of others in a matrixed structure to drive project progress in a timely manner.
- Serves as the functional representative, works with team members from other disciplines, and acts as a senior scientific consultant to provide technical and strategic leadership for research project implementation and coordination.
- Independently finds solutions and develops strategies within area of expertise, uses breadth of knowledge of other disciplines and acts as a scientific resource for BIVP.
- Records experimental design and results in a timely and accurate manner and prepares study reports for internal and regulatory use.
- Scientifically assesses and recommends vendors and outsources nonclinical studies to appropriate contract research organizations.
- Collaborates with automation engineers to identify suitable ways to utilize laboratory automation for the execution of a variety of cell-based assays to enhance throughput and data quality.
- Contributes to multiple projects, interfacing with project teams to meet timelines for project progression.
- Represents the BIVP team to communicate and present research findings clearly and effectively at internal and external meetings.
- Dedicating approximately 30 %–50 % of your time to hands‑on bench work to execute and guide experiments underpinning candidate evaluation
DIMENSIONS AND ASPECTS
Technical/Functional (Line) Expertise
- Experienced in the design, development and implementation of in vitro/ex vivo cell-based functional assays to study target-specific drug effects.
- Knowledgeable and experienced in Cell Biology, Immunology and Antibody characterization.
- Experienced with cell-based functional assay platforms including, but not limited to, on-cell binding, reporter assay, AlphaLISA, MSD, flow cytometry, cell adhesion and migration, organ-on-chip and imaging.
- Experienced in troubleshooting, assay optimization and data quality control are a plus.
- Skilled in data analysis, interpretation, and data reporting.
- Experience and knowledge in Inflammatory diseases and/or fibrosis is a plus.
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
- PhD degree in Immunology, or related scientific discipline with 3+ years of experience, or MS with 9+ years of experience, or BS with 11+ years of experience.
- Industry experience in cell-based assay development and validation.
- Technical knowledge of HTP functional assays and automation experience is a plus.
- Ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality, positive attitude and effective project management skills.
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MA
U.S. Base Salary Range:
$137,000.00 - $215,270.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
YesIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
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